The African Specific DNA Database: A System Outline.

SHORT COMMUNICATION

-----------------------------------------------------

Aboubakar YARI & Venus YARI, Owners

Myra YARI, Marketing Coordinator

-----------------

Abstract:

The advancements in Bioinformatics and genome sequencing generate large amount of genetic data beyond the management capabilities of humans. Computer generated and managed DNA data in databases become essential tools for modern genetics. Numerous DNA databanks have since been developed, including the US National Centre for Biotechnology Information, the EU European Bioinformatics Institute, and the DNA Databank of Japan. The three larger DNA databanks are publicly owned. Numerous task specific private databases have been developed. Here, we describe the African Specific DNA Database, a privately owned subcomponent of the Biotech tropicana Systems SMART African Biotechnology Information Centre.

Keywords: DNA Databank; DNA Database; Genetics; Bioinformatics; Genomics; Public; Private; Database Applications.

Background:

DNA Databanks or DNA Databases

DNA databanks are computer generated large structured file storages that contained many smaller topic specific storages called databases. Databank or database, the two terms may be used interchangeably by different authors base on author set criteria. DNA databanks or DNA databases are specialized for storing, retrieving, and analysing DNA related data. 

Here. we describe the African Specific DNA Database (ASDD), a subcomponent of the SMART African Biotechnology Information Centre (SABIC) platform.

Why an African Specific DNA Database (ASDD)?

Large public databanks such as the US NCBI, the EU EBI, and the japan DDBJ contained contain DNA data in the order of billions to trillions. Searching for a specific data in these databanks may be daunting for non experts. We design the African Specific DNA Database

1.  to reduce the amount of DNA data to search from,
2.  to contain DNA data specific to Africa and Africans
3. to organize data in a manner that is user friendly to non experts of minimal to average expertise in genetics such as specialists in medicine, agronomy, and industry.

System Description:

The African Specific DNA Database (ASDD) is a privately owned DNA database designed to store DNA related data specific to Africa and Africans. The design criteria were previously published [3]. ASDD is q subcomponent of a multiple databases platform called the SMART African Biotechnology information Centre (SABIC), a private program of the Biotech tropicana Systems coordinated by Biotech tropicana,IncAU, a unit of the Science and technology Body of Biotech tropicana Corporation.

Design Specifics:

All databases under SABIC are coordinated from a single control unit called the SABIC Consulting, Inc, designed to operate after incubation as an independent unit of the Biotech tropicana,IncGROUP, the science and technology development body of Biotech tropicana Corporation, a member of the biotech tropicana Systems. [4]

Data organization

Data are stored and organized in sections describing the characteristics of the selected DNA. Selection is based on specificity to Africa and Africans. [x] The data are presented with technical simplicity to make them friendly to users with minimal to average expertise in genetics such as specialists in medicine, agronomy, and industry.

A subsection is created to contain data on business partner of Africa in the field on interest to the selected DNA.

Selected characteristics subject to updates include:

DNA SPECIFIC:  Gene (example)

 NAME: glucose-6-phosphate-déshydrogenase or G6PD (example)

LOCATION:  Chromosome X (source NCBI)

FUNCTION:

The gene codes for a protein enzyme involved in the conversion of glucose to ribose. .

STRUCTURE:

In Process

AFFILIATED TECHNOLOGIES:

PCR, RFLP, SSTR ELECTROPHORESIS.  (Example)

AFRICAN SPECIFIC DATA:

High frequency of disease causing mutated variants of the gene in African populations.  Mutated variants of the gene caused a disease called glucose-6-phosphate-deshydrogenase deficiency, a metabolic disorder that results in hemolysis of red blood cells, due to a defect in conversion of glucose to ribose.

The prevalence of the disease causing mutated variants of the gene was shown to display a high correlation with malaria., a parasitic disease endemic in tropical areas, particularly in Africa. (example)

ADDITIONAL DATA:

The disease causing variants of the gene are also found in tropical areas in ASIA, THE AMERICAS, and the Mediterranean areas in EUROPE.

Appearance of jaundice in African American US military personal and not in white military personal after mass administration of primaquine an anti malaria drug, to both groups under the same condition, led to the hypothesis of an African origin of the disease. Further investigations established a link between the disease and a gene called glucose 6 phosphate dehydrogenase or G6PD. Further works aiming to elucidate the basis of differential response to drug due to gene action led to the establishment of the new field of pharmacogenetics.       

LINKS

Selected web links of special interest to the selected DNA.

REFERENCES:

Selected peer reviewed articles on the selected DNA.

ASDD is under development.

ASDD is accessible through the world wide web at

http://btsabic.ucoz.com/publ/african_specific_dna_database/1-1-0-4

BUSINESS PARTNER DATA:

The high correlation of the disease causing mutated variant of the gene with malaria makes it o gene of special interest to specialist in medicine. Malaria, together with HIV/AIDS and Tuberculosis is one the “BIG 3” global health issues of special interest to the WORLD HEALTH ORGANIZATION, a public business partner of AFRICA, in health issues.

Partner web site is available at www.who.int . Keyword: glucose 6 phosphate dehydrogenase. (example).

ACCESSING Data in ASDD

DNA data stored in ASDD may be retrieved for analysis through two portals:

1. a freely accessible interface, and
2. a restricted interface accessible only by registered users requiring payment of an access fee.

A list of selected databases of the SABIC platform is provided below:

ASLD: African Specific Biotech Literature

ASTD: African Specific Emerging BioTechnologies

ASAD: African Specific LAnguage database

ASSD: African Specific Stock database

ASDD: African Specific DNA database

ASCD: African Specific Biotech Course database.

ASXD: Under conception

DISCUSSION:

ASSD of SABIC is a dynamic database opened to extensions and updates. The ASDD database is dedicated to DNA data specific to Africa and Africans. DNA Data published on the ASDD website are subjected to peer review by experts in the field of interest of the selected DNA data. Short articles of special interest may be published in the Biotech tropicana Systems owned Biotech tropicana Journal. Full articles on topics original to ASDD will be published in international scientific peer review journals.

CONCLUSION:

We described the African Specific DNA Data, a subcomponent of the SMART African Biotechnology information Centre.

Conflict of Interest:

The African Specific DNA Database (ASDD) is subcomponent of the SMART African Biotechnology Information Centre (SABIC) administered by SABIC Consulting, Inc.

SABIC Consulting, Inc. is a unit of the Biotech tropicana Systems, a private biotech company, owned and operated by Aboubakar YARI & Venus YARI.

Biotech tropicana Systems have no affiliation with no other institution that may claim any form of ownership interest in any of its properties. 

Aboubakar YARI & Venus YARI, owners

Myra YARI, Marketing Coordinator.

References:

[1] SABIC Consulting, Inc. at www.btsabic.ucoz.com  

[2]

[3]

[4]

[5]

[6]

[8]

[9]

[10]