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Biotech tropicana Journal, 1(2):4, 2010
Biotech tropicana Journal
Aboubakar YARI & Venus YARI
Biotech tropicana, Inc, Parakou, Benin
*Corresponding Author: Aboubakar YARI, Bioteh tropicana, Inc, 02 Po Box 1038, Parakou, Benin Republic, e-mail: ayari@biotechtropicana.com
Published Online June 15, 2010
Phase I of the SMARThivTECHS Tech trials : A Synthesis
On January 1, 2010, we lunched the clinical trials of the SMARThivTECHS, an HIV patient monitoring system, for the developing world. The trials were organized in three phases, phase 1 covers the simulation trials of the SMARThivTECHS model. Phase II covers the trials of the SMARThivTECHS prototypes in clinical settings, and phase III covers the trials of the SMARThivTECHS products, in clinical settings. Short summaries of the major findings were progressively published in the Biotech tropicana, Inc GROUP Laboratories publication series. (http://btipcrlabs.inventorslab.co.za/ , and http://btielisablogs.inventorslab.co.za/ ).
By March 31, 2010, we established the basic requirements to incorporating the”Life Box” component of the SMARThivTECHS into a motor vehicle, to provide mobility: the "Mobile Life Box”. ((1)(6) BTI PCR PUBLICATIONS at http://btipcrlabs.inventorslab.co.za/ )
In establishing the feasability of the "Mobile Life Box”, the major challenge was to comply with the contamination free PCR laboratory standards within the confined space of a motor vehicle. Contamination is not a big issue in ELISA systems compared to PCR systems. We therefore focus our simulation experiments on the PCR component of the "Life Box”. After six (6) mini publications on the PCR systems versus two (2) on the ELISA system, we demonstrated the feasibility of providing mobility to the "Life Box” while maintaining the contamination control requirement in a standard PCR laboratory. (compare publications in http://btipcrlabs.inventorslab.co.za/ and http://btielisablogs.inventorslab.co.za ).
Using the "trial and error” simulation method, we constructed numerous variants of the "Mobile Life Box” that meet the contamination free PCR laboratory standards. Our mobile models adopted the typical two rooms -four sections linear organization of a typical PCR laboratory. Because ELISA laboratory does not require the rigorous contamination control of the PCR laboratory, we did not repeat the simulation experiment, as applied to the PCR component. However, for esthetic and pursuit of a psychological balance between the PCR and ELISA team, we modeled the ELISA component using the same two rooms-four sections linear organization as applied to the PCR component. Our "Life Box” system predicted a PCR team to execute all PCR related tasks, and an ELISA team to execute all ELISA related tasks. Even where not scientifically justified, we believe that the symetry in the organizations of the PCR and the ELISA components in the "Life Box” will give the two teams a sense of fairness in the partioning of the overall work, and would promote collaboration between the two teams.
While pursuing the simulation experiment of the "Life Box”model, a more detailed description of the "Mobile Life Box” submitted for peer review was accepted and published. (http://www.palgrave-journals.com/jgm/journal/v7/n2/full/jgm20102a.html ). We decided to suspend all mini publications under the Biotech tropicana, Inc GROUP laboratories, to re-analyze all SMARThivTECHS trials related publications, in light of the peer review publication describing the "Mobile Life Box”. Our analysis showed that all data required to move the SMARThivTECHS trials to the second phase in clinical settings are met. However, for esthetic and chronology maintenance for the readers of the mini publications, we decide to add two more mini publications in the ELISA section, to describe how the symetry of organization with the PCR component is achieved.
Negotiations are in progress with hospital settings, to initiate the clinical trials of the prototypes of the SMARThivTECHS system, in "real" hospital settings, to confirm our simulation derived data.
At this point in the process of the trials, we are confident to establish the protocol establishing the feasibility of individual centered "three tests”, in monitoring HIV patients in the resource-poor settings, for presentation to appropriate authorities, by the December 31st , 2010 deadline.
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